Aurora B regulates chromosome segregation and cytokinesis and is the first protein to be implicated as a regulator of bipolar attachment of spindle ...
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What is the function of the Aurora B in mitosis?
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Sep 27, 2022 · Increased Aurora B protein expression, which is common in cancers, is expected to increase Aurora B kinase activity, yielding elevated ...
Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere. AURKB. Available structures.
Aurora B is a key actor of mitosis. Results: The BRAF/ERK axis regulates Aurora B. Vemurafenib-resistant melanoma cells are sensitive to Aurora B inhibition.
May 25, 2023 · An entropy switch controls the Aurora B autoactivation process through two distinct kinetic steps of phosphorylation.
Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player in chromosome segregation. As part of a macromolecular complex ...
Feb 4, 2021 · Aurora B kinase is aberrantly overexpressed in various tumors and shown to be a promising target for anti-cancer therapy.
Apr 28, 2009 · Aurora kinase-A and -B are key regulators of the cell cycle and tumorigenesis. It has remained a mystery why these 2 Aurora kinases, ...
Aurora B kinase is the catalytic subunit of the chromosomal passenger complex (CPC) which also includes regulatory proteins INCENP, Survivin, and Borealin (van ...
Aug 27, 2012 · We present the structure of the human Aurora B kinase domain in complex with the C-terminal Aurora-binding region of human INCENP and the ...